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Research ArticleRegular Article

Polygenic Risk Score Effect on Violent Behavior in Schizophrenia

Christopher Adanty, Jessica Qian, Vincenzo De Luca and Nathan J. Kolla
Journal of the American Academy of Psychiatry and the Law Online June 2023, 51 (2) 236-246; DOI: https://doi.org/10.29158/JAAPL.230007-23
Christopher Adanty
Mr. Adanty and Ms. Qian are Graduate Students at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Dr. De Luca is a Clinician Scientist and Dr. Kolla is a Forensic Psychiatrist at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
MSc
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Jessica Qian
Mr. Adanty and Ms. Qian are Graduate Students at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Dr. De Luca is a Clinician Scientist and Dr. Kolla is a Forensic Psychiatrist at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
BHSc
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Vincenzo De Luca
Mr. Adanty and Ms. Qian are Graduate Students at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Dr. De Luca is a Clinician Scientist and Dr. Kolla is a Forensic Psychiatrist at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
MD, PhD
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Nathan J. Kolla
Mr. Adanty and Ms. Qian are Graduate Students at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Dr. De Luca is a Clinician Scientist and Dr. Kolla is a Forensic Psychiatrist at the Centre for Addiction and Mental Health, Toronto, Ontario, Canada, and the Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
MD, PhD
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  • Figure 1.
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    Figure 1.

    Physical Aggression Binary Polygenic Risk Score Analysis.

  • Figure 2.
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    Figure 2.

    Verbal Aggression Binary Polygenic Risk Score Analysis.

  • Figure 3.
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    Figure 3.

    Aggression against Property Binary Polygenic Risk Score Analysis.

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    Figure 4.

    Physical Quantitative Aggression Polygenic Risk Score Analysis.

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    Figure 5.

    Verbal Quantitative Aggression Polygenic Risk Score Analysis.

  • Figure 6.
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    Figure 6.

    Property Quantitative Aggression Polygenic Risk Score Analysis.

Tables

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    Table 1

    Patient Demographics

    Number of participantsn = 205
    Sex (male/female)145/60
    Age (mean ± SD)42.6 ± 13.0
    Age of onset of SCZ (mean ± SD)22.5 ± 7.9
    Duration of illness (mean ± SD)21.7 ± 13.3
    Smoker (% total)88 (42.9)
    • SD = standard deviation.

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    Table 2

    Aggression and Violence Measures

    Number of Subjects (% total)
     Aggression against Property70 (34.1)
     Verbal Aggression113 (55.4)
     Physical Aggression82 (40.2)
    Aggression/Violence Severity Scores (mean ± SD)
     Aggression against Property0.9 ± 1.4
     Verbal Aggression1.4 ± 1.5
     Physical Aggression1.0 ± 1.3
    • SD = standard deviation.

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Journal of the American Academy of Psychiatry and the Law Online: 51 (2)
Journal of the American Academy of Psychiatry and the Law Online
Vol. 51, Issue 2
1 Jun 2023
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Polygenic Risk Score Effect on Violent Behavior in Schizophrenia
Christopher Adanty, Jessica Qian, Vincenzo De Luca, Nathan J. Kolla
Journal of the American Academy of Psychiatry and the Law Online Jun 2023, 51 (2) 236-246; DOI: 10.29158/JAAPL.230007-23

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Polygenic Risk Score Effect on Violent Behavior in Schizophrenia
Christopher Adanty, Jessica Qian, Vincenzo De Luca, Nathan J. Kolla
Journal of the American Academy of Psychiatry and the Law Online Jun 2023, 51 (2) 236-246; DOI: 10.29158/JAAPL.230007-23
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Keywords

  • aggression/violence
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